I think it would be good for her. I always wanted her to do a little bit more acting since it would be a good way to let go and put in whatever feelings she has. Let it out in away that feel free or connected in away to you, acting can do that for you especially if you feel certain connections or similarities between a certain story or character.
Also I think it would be good start for a comeback plan kinda like how I met you mother was the beginning of her returning to the lime light.
Personally I think she should go after being a main star on a television series. I think it would be a lot easier for her. Considering how the industry is towards woman and age, not saying that she would be able to get could leading movie roles but I think her chances of a getting a good role with a good story line that will be able to show off her acting skills overtime would be a tv series.
I would like to see her first start ( if she was going to return to acting) is a recurring role on a popular or well known TV series. Since she know shonda rimes like most of you have pointed out on here, she should definitely be on grey's anatomy. If it still around by time everything is settle in her life she should be a main/recurring character for a season.
Since it usually a round 24 episodes a season she could do at least 19 episodes. Have her come in as a doctor or some type worker who has a character arc with a beginning middle and end that she learns more about her self and what she wants. Her character would be kinda chill yet sarcastic. Also her character would not die but would come in to some close call threw out the season, but would leave by choice with the option knowing she could come back to the hospital.
Also I would like to see her do another recurring role on a television series wear she would be a villain. I always that when she did Jane the virgin she should have play a recurring character who was nothing but drama, charming, manipulating.
Bonus: wouldn't mind her doing a limted series type of show with Ryan Murphy or bring her ahs like lady gaga in hotel where it certain around her character and being the draw for a season.
So that would be her just starting back into it.
As for the lead/main role in a tv series
I would want it to be about a 13 to 15 episodes hour long pur season . Give her more time to think or do other things with her schedule. Shows example
Heart of Dixie
The flight attendant
Genres would have some type of dramedy or dark comedy to it.